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The Interplay between Zinc,Vitamin D and,IL-17 in Patients with Chronic Hepatitis C Liver Disease
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نویسنده
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reda r. ,abbas a.a. ,mohammed m. ,el fedawy s.f. ,ghareeb h. ,el kabarity r.h. ,abo-shady r.a. ,zakaria d.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Objectives. to assess zinc (zn) and vitamin d (vit. d) status in chronic hepatitis c virus- (hcv) infected patients and their relationship to interleukin- (il-) 17 and disease severity and then investigate whether zn and vit. d3 modulate il-17 expression in chronic hcv patients. methods. seventy patients and fifty healthy subjects were investigated. serum levels of zn,vit. d,and il-17 were assessed in the patients group and subgroups. patients lymphocytes were activated in vitro in the presence or absence of zn or vit. d3 and then intracellular il-17 production was assessed using flow cytometry. results. zn and vit. d were significantly decreased in hcv patients. increasing disease severity leads to more reduction in zn level opposed by increasing il-17 level. zn potently reduced il-17 production in a dose-related fashion; however it did not exert any toxic effects. although vit. d apparently increases il17 expression,it is unclear whether it is due to its toxic effect on cell count or lack of definite association between vit. d and both il-17 and disease severity. conclusions. this study demonstrates that zn modulates il-17 expression and provides a rationale for evaluating this compound as a supplementary agent in the treatment of chronic hcv. © 2015 randa reda et al.
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آدرس
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clinical pathology department,faculty of medicine,ain shams university,abbassia square,p.o. box 11566, Egypt, clinical pathology department,faculty of medicine,ain shams university,abbassia square,p.o. box 11566, Egypt, clinical pathology department,faculty of medicine,ain shams university,abbassia square,p.o. box 11566, Egypt, clinical pathology department,faculty of medicine,ain shams university,abbassia square,p.o. box 11566, Egypt, clinical pathology department,faculty of medicine,ain shams university,abbassia square,p.o. box 11566, Egypt, clinical pathology department,faculty of medicine,ain shams university,abbassia square,p.o. box 11566, Egypt, clinical pathology department,faculty of medicine,ain shams university,abbassia square,p.o. box 11566, Egypt, tropical medicine department,faculty of medicine,ain shams university,abbassia square,p.o. box 11566, Egypt
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Authors
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