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Lactobacillus acidophilus suppresses colitis-associated activation of the IL-23/Th17 axis
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نویسنده
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chen l. ,zou y. ,peng j. ,lu f. ,yin y. ,li f. ,yang j.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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The aim of this paper is to determine the modulatory effects of lactobacillus acidophilus on the il-23/th17 immune axis in experimental colitis. dss-induced mouse models of uc were to be saline,hormones,and different concentrations of lactobacillus acidophilus intervention. the expression of interleukin-(il-) 17,tumor necrosis factor α (tnf α),il-23,transforming growth factor β1 (tgfβ1),signal transducer and activator of transcription 3 (stat3),and phosphorylated (p)-stat3 was examined by rt-pcr,western blotting,and immunohistochemical analysis. and the results showed that administration of l. acidophilus suppressed th17 cell-mediated secretion of proinflammatory cytokine il-17 through downregulation of il-23 and tgfβ1 expression and downstream phosphorylation of p-stat3. © 2015 linlin chen et al.
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آدرس
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department of gastroenterology,xiangya hospital,central south university, China, department of gastroenterology,xiangya hospital,central south university, China, department of gastroenterology,xiangya hospital,central south university, China, department of gastroenterology,second xiangya hospital,central south university, China, department of gastroenterology,xiangya hospital,central south university, China, department of gastroenterology,xiangya hospital,central south university, China, department of gastroenterology,xiangya hospital,central south university, China
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Authors
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