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Effective binding of a phosphatidylserine-targeting antibody to ebola virus infected cells and purified virions
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نویسنده
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dowall s.d. ,graham v.a. ,corbin-lickfett k. ,empig c. ,schlunegger k. ,bruce c.b. ,easterbrook l. ,hewson r.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Ebola virus is responsible for causing severe hemorrhagic fevers,with case fatality rates of up to 90%. currently,no antiviral or vaccine is licensed against ebola virus. a phosphatidylserine-targeting antibody (pgn401,bavituximab) has previously been shown to have broad-spectrum antiviral activity. here,we demonstrate that pgn401 specifically binds to ebola virus and recognizes infected cells. our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against ebola virus. © 2015 s. d. dowall et al.
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آدرس
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public health england,porton down,wiltshire, United Kingdom, public health england,porton down,wiltshire, United Kingdom, peregrine pharmaceuticals,inc.,tustin, United States, peregrine pharmaceuticals,inc.,tustin, United States, peregrine pharmaceuticals,inc.,tustin, United States, public health england,porton down,wiltshire, United Kingdom, public health england,porton down,wiltshire, United Kingdom, public health england,porton down,wiltshire, United Kingdom
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Authors
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