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The Role of Intestinal Microbiota in Acute Graft-versus-Host Disease
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نویسنده
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chen y. ,zhao y. ,cheng q. ,wu d. ,liu h.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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The mammalian intestinal microbiota is a complex ecosystem that plays an important role in host immune responses. recent studies have demonstrated that alterations in intestinal microbiota composition are linked to multiple inflammatory diseases in humans,including acute graft-versus-host disease (agvhd). agvhd is one of the major obstacles in allogeneic hematopoietic stem cell transplantation (allo-hsct),characterized by tissue damage in the gastrointestinal (gi) tract,liver,lung,and skin. here,we review the current understanding of the role of intestinal microbiota in the control of immune responses during agvhd. additionally,the possibility of using probiotic strains for potential treatment or prevention of agvhd will be discussed. copyright © 2015 yuanyuan chen et al.
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آدرس
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laboratory of cellular and molecular tumor immunology,institutes of biology and medical sciences,soochow university, China, cyrus tang hematology center,department of hematology,soochow university, China, laboratory of cellular and molecular tumor immunology,institutes of biology and medical sciences,soochow university, China, cyrus tang hematology center,department of hematology,soochow university, China, laboratory of cellular and molecular tumor immunology,institutes of biology and medical sciences,soochow university,suzhou,china,cyrus tang hematology center,department of hematology,soochow university, China
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Authors
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