Relative movements of domains in large molecules of the immune system

Molecular dynamics was used to simulate large molecules of the immune system (major histocompatibility complex class i,presented epitope,t-cell receptor,and a cd8 coreceptor.) to characterize the relative orientation and movements of domains local coordinate systems (based on principal component analysis) were generated and directional cosines and euler angles were computed. as a most interesting result,we found that the presence of the coreceptor seems to influence the dynamics within the protein complex,in particular the relative movements of the two α-helices,gαand gα © 2015 wolfgang schreiner et al.