Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease

Behçet's disease (bd) is a multisystem inflammatory disorder characterized by orogenital ulcerations,ocular manifestations,arthritis,and vasculitis. the disease follows a relapsing-remitting course and its pathogenesis is unknown. genetic predisposition and immune-dysregulation involving gamma delta (γδ) t cells are reported to have a role. γδ t cells are atypical t cells,which represent a small proportion of total lymphocytes. they have features of both innate and adaptive immunity and express characteristics of conventional t cells,natural killer cells,and myeloid antigen presenting cells. these unconventional t cells are found in the inflammatory bd lesions and have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of the disease. over the last 20 years there has been much interest in the role of γδ t cells in bd. we review the literature and discuss the roles that γδ t cells may play in bd pathogenesis. © 2015 md. samiul hasan et al.