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CD69 is the crucial regulator of intestinal inflammation: A new target molecule for IBD treatment?
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نویسنده
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radulovic k. ,niess j.h.
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منبع
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journal of immunology research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Cd69 has been identified as an early activation marker of lymphocytes. however,recent work has indicated that cd69 plays an essential role for the regulation of inflammatory processes. particularly,cd69 is highly expressed by lymphocytes at mucosal sites being constantly exposed to the intestinal microflora (one of the nature's most complex and most densely populated microbial habitats) and food antigens,while only a small number of circulating leukocytes express this molecule. in this review we will discuss the role of cd69 in mucosal tissue and consider cd69 as a potential target for the development of novel treatments of intestinal inflammation. © 2015 katarina radulovic and jan hendrik niess.
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آدرس
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u1019,team 7,institut national de la santé et de la recherche médicale (inserm),1 rue du professeur calmette,lille,france,center for infection and immunity of lille,institut pasteur de lille,1 rue du professeur calmette, France, department of visceral surgery and medicine,inselspital,freiburgstraße, Switzerland
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Authors
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