The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation

Objective. systemic lupus erythematosus (sle) is an autoimmune disease identified by a plethora of production of autoantibodies. autoreactive t cells may play an important role in the process. attenuated t cell vaccination (tcv) has proven to benefit some autoimmune diseases by deleting or suppressing pathogenic t cells. however,clinical evidence for tcv in sle is still limited. therefore,this self-controlled study concentrates on the clinical effects of tcv on sle patients. methods. 16 patients were enrolled in the study; they accepted tcv regularly. sledai,clinical symptoms,blood parameters including complements 3 and 4 levels,ana,and anti-ds-dna antibodies were tested. in addition,the side effects and drug usage were observed during the patients' treatment and follow-up. results. remissions in clinical symptoms such as facial rash,vasculitis,and proteinuria were noted in most patients. there are also evident reductions in sledai,anti-ds-dna antibodies,and gc dose and increases in c3 and c4 levels,with no pathogenic side effects during treatment and follow-up. conclusions. t cell vaccination is helpful in alleviating and regulating systemic lupus erythematosus manifestation. © 2016 liuye huang et al.