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Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival,Biomarkers,and Improved Response to CTLA-4 Blockade
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نویسنده
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lotem m. ,merims s. ,frank s. ,hamburger t. ,nissan a. ,kadouri l. ,cohen j. ,straussman r. ,eisenberg g. ,frankenburg s. ,carmon e. ,alaiyan b. ,shneibaum s. ,ayyildiz z.o. ,isbilen m. ,senses k.m. ,ron i. ,steinberg h. ,smith y. ,shiloni e. ,gure a.o. ,peretz t.
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منبع
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journal of immunology research - 2016 - دوره : 2016 - شماره : 0
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چکیده
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Background. there is not yet an agreed adjuvant treatment for melanoma patients with american joint committee on cancer stages iii b and c. we report administration of an autologous melanoma vaccine to prevent disease recurrence. patients and methods. 126 patients received eight doses of irradiated autologous melanoma cells conjugated to dinitrophenyl and mixed with bcg. delayed type hypersensitivity (dth) response to unmodified melanoma cells was determined on the vaccine days 5 and 8. gene expression analysis was performed on 35 tumors from patients with good or poor survival. results. median overall survival was 88 months with a 5-year survival of 54%. patients attaining a strong dth response had a significantly better (p = 0.0001) 5-year overall survival of 75% compared with 44% in patients without a strong response. gene expression array linked a 50-gene signature to prognosis,including a cluster of four cancer testis antigens: ctag2 (ny-eso-2),magea1,ssx1,and ssx4. thirty-five patients,who received an autologous vaccine,followed by ipilimumab for progressive disease,had a significantly improved 3-year survival of 46% compared with 19% in nonvaccinated patients treated with ipilimumab alone (p = 0.007). conclusion. improved survival in patients attaining a strong dth and increased response rate with subsequent ipilimumab suggests that the autologous vaccine confers protective immunity. � 2016 michal lotem et al.
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آدرس
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sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel, sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel, sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel, sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel, departments of surgery,hadassah hebrew university hospital,mount scopus campus,jerusalem, Israel, sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel, sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel, department of molecular cell biology,weizmann institute of science,rehovot, Israel, sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel, sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel, departments of surgery,hadassah hebrew university hospital,mount scopus campus,jerusalem, Israel, departments of surgery,hadassah hebrew university hospital,mount scopus campus,jerusalem, Israel, department of surgery,tel aviv sourasky medical center,tel aviv, Israel, department of molecular biology and genetics,bilkent university,ankara, Turkey, department of molecular biology and genetics,bilkent university,ankara, Turkey, department of molecular biology and genetics,bilkent university,ankara, Turkey, department of oncology,tel aviv sourasky medical center,tel aviv, Israel, sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel, genomic data analysis unit,hebrew university medical school,jerusalem, Israel, department of surgery,bnai zion medical center,haifa, Israel, department of molecular biology and genetics,bilkent university,ankara, Turkey, sharett institute of oncology,hadassah hebrew university hospital,ein karem campus,jerusalem, Israel
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Authors
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