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Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors
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نویسنده
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qian h. ,xuan j. ,liu y. ,shi g.
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منبع
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journal of immunology research - 2016 - دوره : 2016 - شماره : 0
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چکیده
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The g-protein-coupled estrogen receptor-1 (gper-1),also known as gpr30,is a novel estrogen receptor mediating estrogen receptor signaling in multiple cell types. the progress of estrogen-related cancer is promoted by gper-1 activation through mitogen-activated protein kinases (mapk),phosphoinositide 3-kinase (pi3k),and phospholipase c (plc) signaling pathways. however,this promoting effect of gper-1 is nonclassic estrogen receptor (er) dependent manner. in addition,clinical evidences revealed that gper-1 is associated with estrogen resistance in estrogen-related cancer patients. these give a hint that gper-1 may be a novel therapeutic target for the estrogen-related cancers. however,preclinical studies also found that gper-1 activation of its special agonist g-1 inhibits cancer cell proliferation. this review aims to summarize the characteristics and complex functions of gper-1 in cancers. � 2016 hongyan qian et al.
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آدرس
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department of rheumatology and clinical immunology,first affiliated hospital of xiamen university,xiamen, China, department of rheumatology and clinical immunology,first affiliated hospital of xiamen university,xiamen, China, department of rheumatology and clinical immunology,first affiliated hospital of xiamen university,xiamen, China, department of rheumatology and clinical immunology,first affiliated hospital of xiamen university,xiamen, China
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Authors
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