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The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation
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نویسنده
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zhang c. ,wang s. ,yang c. ,rong r.
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منبع
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journal of immunology research - 2016 - دوره : 2016 - شماره : 0
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چکیده
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Myeloid derived suppressor cells (mdscs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions. recent studies have uncovered the crosstalk between mdscs and immune cells (i.e.,natural killer cells,dendritic cells,macrophages,natural killer t cells,and regulatory t cells) and its role in the establishment and maintenance of immune tolerant microenvironment in transplantation. considering their strong immunosuppressive capability,mdscs could become a prospective clinical regimen during transplantation tolerance induction,resulting in long-term graft survival with decreased or without immunosuppressive drugs. the review summarized recent research advances in this field and looked ahead at the research directions in the future. � 2016 chao zhang et al.
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آدرس
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department of urology,zhongshan hospital,fudan university,shanghai,china,shanghai key laboratory of organ transplantation,shanghai, China, department of urology,zhongshan hospital,fudan university,shanghai,china,shanghai key laboratory of organ transplantation,shanghai, China, shanghai key laboratory of organ transplantation,shanghai,china,department of plastic surgery,zhongshan hospital,fudan university,shanghai, China, department of urology,zhongshan hospital,fudan university,shanghai,china,shanghai key laboratory of organ transplantation,shanghai,china,department of transfusion,zhongshan hospital,fudan university,shanghai, China
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Authors
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