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Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation
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نویسنده
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li f. ,wang y. ,lin l. ,wang j. ,xiao h. ,li j. ,peng x. ,dai h. ,li l.
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منبع
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journal of immunology research - 2016 - دوره : 2016 - شماره : 0
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چکیده
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Exosomes are nanovesicles released by different cell types,such as dendritic cells (dcs),mast cells (mcs),and tumor cells. exosomes of different origin play a role in antigen presentation and modulation of immune response to infectious disease. in this study,we demonstrate that mast cells and cd4+ t cells colocated in peritoneal lymph nodes from balb/c mouse. further,bone marrow-derived mast cells (bmmcs) constitutively release exosomes,which express cd63 and ox40l. bmmc-exosomes partially promoted the proliferation of cd4+ t cells. bmmc-exosomes significantly enhanced the differentiation of naive cd4+ t cells to th2 cells in a surface contact method,and this ability was partly inhibited by the addition of anti-ox40l ab. in conclusion,bmmc-exosomes promoted the proliferation and differentiation of th2 cells via ligation of ox40l and ox40 between exosomes and t cells. this method represents a novel mechanism,in addition to direct cell surface contacts,soluble mediators,and synapses,to regulate t cell actions by bmmc-exosomes. © 2016 fei li et al.
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آدرس
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department of laboratory medicine,shanghai first people's hospital,shanghai jiao tong university school,shanghai, China, department of laboratory medicine,shanghai first people's hospital,shanghai jiao tong university school,shanghai, China, department of laboratory medicine,shanghai first people's hospital,shanghai jiao tong university school,shanghai, China, department of laboratory medicine,shanghai first people's hospital,shanghai jiao tong university school,shanghai, China, department of laboratory medicine,shanghai first people's hospital,shanghai jiao tong university school,shanghai, China, department of laboratory medicine,shanghai first people's hospital,shanghai jiao tong university school,shanghai, China, department of laboratory medicine,shanghai first people's hospital,shanghai jiao tong university school,shanghai, China, department of laboratory medicine,shanghai first people's hospital,shanghai jiao tong university school,shanghai, China, department of laboratory medicine,shanghai first people's hospital,shanghai jiao tong university school,shanghai, China
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Authors
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