Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy

Background. the il-33/st2 axis is involved in humoral immune responses. method. the concentrations of sera il-33 and sst2 in 74 patients and 34 healthy controls (hc) were measured by elisa. clinical and laboratory data were examined. the potential association between sera il-33 and sst2 and the clinical parameters in igan patients were analyzed. results. no difference was discovered in il-33 concentrations between igan patients and hcs; however,the sst2 were significantly higher in each stage of igan progression than in the hc. the concentration of sst2 was positively correlated with il-33 levels in igan patients. higher levels of sera il-2,il-4,il-10,il-17a,and ifn-γ were detected in patients compared to the hc. the concentration of serum sst2 was positively correlated with the levels of il-10 in igan patients. furthermore,serum sst2 was negatively correlated with the values of egfr and serum calcium. serum sst2 was positively correlated with 24-hour urinary protein,serum phosphorus,and serum iga; however,serum il-33 was not associated with these. following treatment,serum sst2 was significantly decreased,while sera il-4 and il-10 were significantly increased. conclusions. increased sst2 and il-10 but not il-33 may be involved in the pathogenic process of igan. © 2016 zhihui zhang et al.