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Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
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نویسنده
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harris r.a. ,shah r. ,hollister e.b. ,tronstad r.r. ,hovdenak n. ,szigeti r. ,versalovic j. ,kellermayer r.
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منبع
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journal of immunology research - 2016 - دوره : 2016 - شماره : 0
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چکیده
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Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (ibds) including crohn's disease (cd) and ulcerative colitis (uc),which are linked to early onset colorectal cancer (crc). colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by infinium humanmethylation450 beadchips and,in 10 cases,by 454 pyrosequencing of the bacterial 16s rrna gene. intercalating age-specific dna methylation and microbiome changes were identified,which may have significant translational relevance in the developmental origins of ibd and crc. © 2016 r. alan harris et al.
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آدرس
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department of molecular and human genetics,baylor college of medicine,houston,tx, United States, section of gastroenterology and hepatology,baylor college of medicine,houston,tx, United States, department of pathology and immunology,baylor college of medicine,houston,tx,united states,texas children's hospital,houston,tx, United States, department of clinical science,university of bergen,bergen,norway,department of pediatrics,haukeland university hospital,bergen, Norway, department of clinical medicine,university of bergen,bergen, Norway, department of pathology and immunology,baylor college of medicine,houston,tx, United States, department of pathology and immunology,baylor college of medicine,houston,tx,united states,texas children's hospital,houston,tx, United States, texas children's hospital,houston,tx,united states,section of pediatric gastroenterology,department of pediatrics,baylor college of medicine,houston,tx,united states,usda,ars children's nutrition research center,houston,tx, United States
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Authors
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