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   Sensitivity of dendritic cells to microenvironment signals  
   
نویسنده motta j.m. ,rumjanek v.m.
منبع journal of immunology research - 2016 - دوره : 2016 - شماره : 0
چکیده    Dendritic cells are antigen-presenting cells capable of either activating the immune response or inducing and maintaining immune tolerance. they do this by integrating stimuli from the environment and changing their functional status as a result of plasticity. the modifications suffered by these cells have consequences in the way the organism may respond. in the present work two opposing situations known to affect dendritic cells are analyzed: tumor growth,leading to a microenvironment that favors the induction of a tolerogenic profile,and organ transplantation,which leads to a proinflammatory profile. lessons learned from these situations may help to understand the mechanisms of modulation resulting not only from the above circumstances,but also from other pathologies. © 2016 juliana maria motta and vivian mary rumjanek.
آدرس laboratório de imunologia tumoral,instituto de bioquímica médica leopoldo de meis,universidade federal do rio de janeiro,rio de janeiro,rj, Brazil, laboratório de imunologia tumoral,instituto de bioquímica médica leopoldo de meis,universidade federal do rio de janeiro,rio de janeiro,rj, Brazil
 
     
   
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