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Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes
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نویسنده
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lin j. ,cheon j. ,brown r. ,coccia m. ,puterman e. ,aschbacher k. ,sinclair e. ,epel e. ,blackburn e.h.
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منبع
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journal of immunology research - 2016 - دوره : 2016 - شماره : 0
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چکیده
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Telomeres,the protective dna-protein complexes at the ends of linear chromosomes,are important for genome stability. leukocyte or peripheral blood mononuclear cell (pbmc) telomere length is a potential biomarker for human aging that integrates genetic,environmental,and lifestyle factors and is associated with mortality and risks for major diseases. however,only a limited number of studies have examined longitudinal changes of telomere length and few have reported data on sorted circulating immune cells. we examined the average telomere length (tl) in cd4+,cd8+cd28+,and cd8+cd28- t cells,b cells,and pbmcs,cross-sectionally and longitudinally,in a cohort of premenopausal women. we report that tl changes over 18 months were correlated among these three t cell types within the same participant. additionally,pbmc tl change was also correlated with those of all three t cell types,and b cells. the rate of shortening for b cells was significantly greater than for the three t cell types. cd8+cd28- cells,despite having the shortest tl,showed significantly more rapid attrition when compared to cd8+cd28+ t cells. these results suggest systematically coordinated,yet cell type-specific responses to factors and pathways contribute to telomere length regulation. copyright © 2016 jue lin et al.
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آدرس
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department of biochemistry and biophysics,university of california san francisco,san francisco,ca, United States, department of biochemistry and biophysics,university of california san francisco,san francisco,ca, United States, division of epidemiology,university of california berkeley,berkeley,ca, United States, department of psychiatry,university of california san francisco,san francisco,ca, United States, school of kinesiology,university of british columbia,vancouver,bc, Canada, department of psychiatry,university of california san francisco,san francisco,ca, United States, core immunology lab,division of experimental medicine,university of california san francisco,san francisco,ca, United States, department of psychiatry,university of california san francisco,san francisco,ca, United States, department of biochemistry and biophysics,university of california san francisco,san francisco,ca, United States
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Authors
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