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Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κ B Pathway
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نویسنده
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yang j.-t. ,lee i.-n. ,lu f.-j. ,chung c.-y. ,lee m.-h. ,cheng y.-c. ,chen k.-t. ,chen c.-h.
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منبع
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journal of immunology research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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In this study,we demonstrated that temozolomide (tmz) and propyl gallate (pg) combination enhanced the inhibition of migration in human u87mg glioma cells. pg inhibited the tmz-induced reactive oxygen species (ros) generation. the mitochondrial complex iii and nadph oxidase are two critical sites that can be considered to regulate antimigration in tmz-treated u87mg cells. pg can enhance the antimigration effect of tmz through suppression of metalloproteinase-2 and metalloproteinase-9 activities,ros generation,and the nf-κb pathway and possibly provide a novel prospective strategy for treating malignant glioma. © 2017 jen-tsung yang et al.
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آدرس
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department of neurosurgery,chang gung memorial hospital,chiayi,taiwan,college of medicine,chang gung university,tao-yuan, Taiwan, department of medical research,chang gung memorial hospital,chiayi, Taiwan, institute of medicine,chung shan medical university,taichung, Taiwan, department of neurosurgery,chang gung memorial hospital,chiayi, Taiwan, department of neurosurgery,chang gung memorial hospital,chiayi, Taiwan, department of neurosurgery,chang gung memorial hospital,chiayi, Taiwan, department of neurosurgery,chang gung memorial hospital,chiayi, Taiwan, department of microbiology,immunology and biopharmaceuticals,college of life sciences,national chiayi university,chiayi city, Taiwan
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Authors
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