Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies

Humoral deficiencies represent a broad group of disorders. the aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-pcp) and natural anti-galactosyl (anti-gal) antibodies in (1) patients with chronic lymphocytic leukaemia (cll),(2) patients with common variable immunodeficiency (cvid),and (3) a healthy population and to explore their diagnostic and prognostic potential. serum immunoglobulin levels and levels of anti-gal igg,iga,and igm and anti-pcp igg and igg2 were determined in 59 cll patients,30 cvid patients,and 67 healthy controls. levels of igg,iga,igm,anti-gal iga,anti-gal igm,and anti-pcp iga were lower in cll and cvid patients than in healthy controls (p value for all parameters < 0.0001). decrease in the levels of iga,igm,anti-gal iga,and anti-pcp iga was less pronounced in the cll group than in the cvid group. iga decline,anti-gal iga,anti-pcp iga,and anti-pcp igg2 were negatively correlated with cll stage. we devise the evaluation of anti-gal antibodies to be a routine test in humoral immunodeficiency diagnostics,even in cases of immunoglobulin substitution therapy. significant reductions,mainly in anti-gal iga,igm,and anti-pcp iga levels,may have prognostic importance in cll patients. © 2017 p. kralickova et al.