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Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis
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نویسنده
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yang f. ,wang d. ,li y. ,sang l. ,zhu j. ,wang j. ,wei b. ,lu c. ,sun x.
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منبع
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journal of immunology research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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Background. the role of the th17/treg balance in the development of experimental colitis remains poorly understood. methods. we exploited the differential response of balb/c mice and c57bl/6 mice towards drinking water mediated by dextran sulfate sodium (dss) challenge. results. dss-resistant balb/c mice were characterized by low levels of ifn-γ and tnf-α but high levels of il-4,il-6,il-10,il-17a,il-17f,and colon lamina propria and mesenteric lymph node (mln) cd4+cd25+foxp3+ t cells when compared to c57bl/6 mice. collectively,these data indicate the propensity of balb/c mice towards a th2/th17/treg-polarized immunity protecting these animals against dss challenge,whereas th1-polarization of c57bl/6 mice confers sensitivity to dss-induced colitis. conclusions. the intrinsic congenital capacity of mouse strains with respect to t cell proliferation determines sensitivity to experimental colitis. © 2017 fangli yang et al.
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آدرس
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department of immunology,china medical university,shenyang,china,department of immunology,college of basic medical sciences,shenyang medical college,shenyang, China, department of immunology,china medical university,shenyang, China, department of immunology,china medical university,shenyang, China, department of immunology,china medical university,shenyang, China, department of immunology,china medical university,shenyang, China, department of immunology,china medical university,shenyang, China, department of immunology,china medical university,shenyang, China, department of immunology,china medical university,shenyang, China, department of immunology,china medical university,shenyang, China
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Authors
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