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Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection
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نویسنده
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al-anazi m.r. ,matou-nasri s. ,abdo a.a. ,sanai f.m. ,alkahtani s. ,alarifi s. ,alkahtane a.a. ,al-yahya h. ,ali d. ,alessia m.s. ,alshahrani b. ,al-ahdal m.n. ,al-qahtani a.a.
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منبع
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journal of immunology research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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Toll-like receptor 3 (tlr3) plays a key role in innate immunity by recognizing pathogenic,double-stranded rnas. thus,activation of tlr3 is a major factor in antiviral defense and tumor eradication. although downregulation of tlr3 gene expression has been mainly reported in patients infected with hepatitis c virus (hcv),the influence of tlr3 genotype on the risk of hcv infection,hcv-related cirrhosis,and/or hepatocellular carcinoma (hcc) remains to be determined. single-nucleotide polymorphisms (snps) within the tlr3 gene and their associations with hcv-related disease risk were investigated in a saudi arabian population in this study. eight tlr3 snps were analyzed in 563 patients with hcv,which consisted of 437 patients with chronic hcv infections,88 with hcv-induced liver cirrhosis,and 38 with hcc. a total of 599 healthy control subjects were recruited to the study. among the eight tlr3 snps studied,the rs78726532 snp was strongly associated with hcv infection when compared to that in healthy control subjects. the rs5743314 was also strongly associated with hcv-related liver disease progression (cirrhosis and hcc). in summary,these results indicate that distinct genetic variants of tlr3 snps are associated with hcv infection and hcv-mediated liver disease progression in the saudi arabian population. © 2017 mashael r. al-anazi et al.
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آدرس
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department of infection and immunity,research center,king faisal specialist hospital and research center,riyadh, Saudi Arabia, cell and gene therapy group,medical genomics research department,king abdullah international medical research center,ministry of national guard,riyadh, Saudi Arabia, section of gastroenterology,department of medicine,college of medicine,king saud university,riyadh,saudi arabia,liver disease research center,king saud university,riyadh, Saudi Arabia, liver disease research center,king saud university,riyadh,saudi arabia,gastroenterology unit,department of medicine,king abdulaziz medical city,jeddah, Saudi Arabia, department of zoology,science college,king saud university,riyadh, Saudi Arabia, department of zoology,science college,king saud university,riyadh, Saudi Arabia, department of zoology,science college,king saud university,riyadh, Saudi Arabia, department of zoology,science college,king saud university,riyadh, Saudi Arabia, department of zoology,science college,king saud university,riyadh, Saudi Arabia, department of biology,science college,ai-imam muhammad ibn saud islamic university,riyadh, Saudi Arabia, department of infection and immunity,research center,king faisal specialist hospital and research center,riyadh, Saudi Arabia, department of infection and immunity,research center,king faisal specialist hospital and research center,riyadh,saudi arabia,department of microbiology and immunology,alfaisal university school of medicine,riyadh, Saudi Arabia, department of infection and immunity,research center,king faisal specialist hospital and research center,riyadh,saudi arabia,department of microbiology and immunology,alfaisal university school of medicine,riyadh, Saudi Arabia
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Authors
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