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Mannose-Binding Lectin: Biologic Characteristics and Role in the Susceptibility to Infections and Ischemia-Reperfusion Related Injury in Critically Ill Neonates
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نویسنده
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auriti c. ,prencipe g. ,moriondo m. ,bersani i. ,bertaina c. ,mond� v. ,inglese r.
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منبع
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journal of immunology research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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The mannose-binding lectin (mbl) is a member of the collectin family,belonging to the innate immunity system. genetic,biologic,and clinical properties of mbl have been widely investigated throughout the last decades,although some interesting aspects of its potential clinical relevance are still poorly understood. low circulating concentrations of mbl have been associated with increased risk of infection and poor neurologic outcome in neonates. on the other hand,an excessive and uncontrolled inflammatory response by the neonatal intestine after the exposure to luminal bacteria,leading to an increased production of mbl,may be involved in the onset of necrotizing enterocolitis. the purpose of the present review is to summarize the current knowledge about genetic and biologic characteristics of mbl and its role in the susceptibility to infections and to ischemia-reperfusion related tissue injuries to better explore its clinical relevance during the perinatal period and the possible future therapeutic applications. � 2017 cinzia auriti et al.
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آدرس
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department of medical and surgical neonatology,bambino ges� children's hospital (irccs),piazza s. onofrio 4,rome, Italy, department of laboratories,laboratory of rheumatology,bambino ges� children's hospital (irccs),piazza s. onofrio 4,rome, Italy, department of pediatrics,anna meyer children's university hospital,viale gaetano pieraccini 24,florence, Italy, department of medical and surgical neonatology,bambino ges� children's hospital (irccs),piazza s. onofrio 4,rome, Italy, department of medical and surgical neonatology,bambino ges� children's hospital (irccs),piazza s. onofrio 4,rome, Italy, department of medical and surgical neonatology,bambino ges� children's hospital (irccs),piazza s. onofrio 4,rome, Italy, department of laboratories,laboratory of chemical chemistry,bambino ges� children's hospital (irccs),piazza s. onofrio 4,rome, Italy
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Authors
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