Impacts of Anti-dsDNA Antibody on in Vitro Fertilization-Embryo Transfer and Frozen-Thawed Embryo Transfer

Our purpose is to explore whether anti-dsdna antibody,which was demonstrated to enter living cells and induced apoptosis,could adversely affect reproductive outcomes. a total of 259 women receiving the in vitro fertilization-embryo transfer (ivf) cycle were enrolled in this study,including 52 women with positive ana and anti-dsdna (ana+/anti-dsdna+ group),86 women with positive ana and negative anti-dsdna (ana+/anti-dsdna-group),and 121 women with negative ana and anti-dsdna (ana-/anti-dsdna-group). 136 nonpregnant women among 259 patients in the ivf-et cycle were enrolled in the hormone replacement therapy frozen-thawed embryo transfer (hrt-tet) cycle. we compared basic characters and ivf outcomes among three groups in fresh embryo transfer and frozen-thawed embryo transfer cycle,respectively. the number of retrieved oocytes,available embryos,and high-quality embryos in the ana+/anti-dsdna+ group was lower than those in the other two groups in the fresh embryo transfer cycle. the rates of fertilization,implantation,and clinical pregnancy in the ana+/anti-dsdna+ group were the lowest,while the early miscarriage rate was the highest in the ana+/anti-dsdna+ group both in the fresh embryo transfer cycle and in the frozen-thawed embryo transfer cycle. our data suggested that anti-dsdna antibody may be the essential marker for defective oocytes or embryos in infertile women with any type of ana. © 2017 jiao fan et al.