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Immunomodulatory Effect of Flavonoids of Blueberry (Vaccinium corymbosum L.) Leaves via the NF- κ B Signal Pathway in LPS-Stimulated RAW 264.7 Cells
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نویسنده
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shi d. ,xu m. ,ren m. ,pan e. ,luo c. ,zhang w. ,tang q.
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منبع
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journal of immunology research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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Objective. this study aimed to explore the immunoregulatory effect of flavonoids of blueberry (vaccinium corymbosum l.) leaves (fbl). methods. the flavonoids of blueberry leaves were prepared with 70% ethanol and were identified by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry (uplc/q-tof-ms). the immunoregulatory effect and possible regulatory mechanisms of fbl were investigated in lipopolysaccharide- (lps-) induced raw 264.7 cells. results. according to the results of uplc/q-tof-ms,nine flavonoids of blueberry leaves were identified. fbl showed a significant reduction in the production of tnf-α in lps-stimulated raw 264.7 cells. fbl significantly decreased the expression of nf-κb p65 and p-nf-κb p65 in lps-induced raw 264.7 cells in a dose-dependent manner. conclusion. our study showed the immunoregulatory effect of fbl through the suppression of tnf-α via the nf-κb signal pathway. © 2017 dazhi shi et al.
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آدرس
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school of traditional chinese medicine,southern medical university,guangzhou,china,guangdong provincial key laboratory of chinese medicine pharmaceutics,southern medical university,guangzhou, China, school of traditional chinese medicine,southern medical university,guangzhou,china,guangdong provincial key laboratory of chinese medicine pharmaceutics,southern medical university,guangzhou, China, school of traditional chinese medicine,southern medical university,guangzhou,china,guangdong provincial key laboratory of chinese medicine pharmaceutics,southern medical university,guangzhou, China, school of traditional chinese medicine,southern medical university,guangzhou, China, school of traditional chinese medicine,southern medical university,guangzhou, China, state key laboratory of quality research in chinese medicines,macau institute for applied research in medicine and health,macau university of science and technology,taipa, Macau, school of traditional chinese medicine,southern medical university,guangzhou,china,guangdong provincial key laboratory of chinese medicine pharmaceutics,southern medical university,guangzhou, China
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Authors
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