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   Protective Effects of Ophiocordyceps lanpingensis on Glycerol-Induced Acute Renal Failure in Mice  
   
نویسنده zhang y. ,du y. ,yu h. ,zhou y. ,ge f.
منبع journal of immunology research - 2017 - دوره : 2017 - شماره : 0
چکیده    Objective. oxidative stress and immune response are associated with acute renal failure (arf). ophiocordyceps lanpingensis (ol) might be an antioxidant and immunopotentiator. in this study,we explored the protective effects of ol on glycerol-induced arf. methods. male mice were randomly divided into four groups,specifically,glycerol-induced arf model group,low-dose ol-treated group (1.0 g/kg/d),high-dose ol-treated group (2.0 g/kg/d),and control group. renal conditions were evaluated using kidney index,serum creatinine (cr),blood urea nitrogen (bun),and histological analysis. rhabdomyolysis was monitored using creatine kinase (ck) level. oxidative stress was determined using kidney tissue glutathione (gsh),malondialdehyde (mda),and superoxide dismutase (sod) levels. immune status was evaluated using immune organ indices and immunoglobulin g (igg) level. results. ol could relieve renal pathological injury and decrease the abnormal levels of kidney index,serum cr,ck,bun,and mda,as well as increase the immune organ indices and the levels of igg,gsh,and sod. treatment with a high dose of ol had more positive therapeutic effects on arf than using a low dose of ol. conclusion. ol could ameliorate renal dysfunction in glycerol-induced arf in mice by inhibiting oxidative stress and enhancing immune response. © 2017 yanyan zhang et al.
آدرس faculty of life science and technology,kunming university of science and technology,kunming,yunnan, China, tumor research institute of yunnan province,third affiliated hospital,kunming medical university (yunnan tumor hospital),kunming,yunnan, China, school of life sciences,yunnan university,kunming,yunnan,china,research center of cordyceps development and utilization of kunming,kunming,yunnan, China, tumor research institute of yunnan province,third affiliated hospital,kunming medical university (yunnan tumor hospital),kunming,yunnan, China, faculty of life science and technology,kunming university of science and technology,kunming,yunnan,china,research center of cordyceps development and utilization of kunming,kunming,yunnan, China
 
     
   
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