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Association of Toll-Like Cell Receptors TLR2 (p.Arg753GLN) and TLR4 (p.Asp299GLY) Polymorphisms with Indicators of General and Local Immunity in Patients with Atopic Dermatitis
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نویسنده
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tyurin y.a. ,shamsutdinov a.f. ,kalinin n.n. ,sharifullina a.a. ,reshetnikova i.d.
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منبع
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journal of immunology research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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A whole group of polymorphisms of genes involved in the formation of the epidermal barrier,immune responses,and their regulation is important in the formation of atopic phenotype. the purpose of the study is to determine the relationship of polymorphisms of genes of toll-like receptors tlr2 and tlr4 with clinical and immunological parameters in atopic dermatitis patients in a case-control study. polymorphisms of genes tlr2 (p.arg753gln) and tlr4 (asp299gly) were detected by pcr. parameters of the state of innate and adaptive immunity were assessed by the level of local production of siga,cytokine profile of blood serum for il-4,il-10,and ifn-γ. biological samples from 50 people with allergic pathology,aged 4.5 to 35 years,and 100 healthy individuals (controls) were analyzed. observed dysregulation of cytokine production (il-4,il-10) in patients with heterozygous polymorphic genotypes probably reflects an imbalance of th1/th2/th17 regulation of immune system response in these individuals. © 2017 yury a. tyurin et al.
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آدرس
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department of biochemistry and clinical laboratory diagnostics,kazan state medical university,49 butlerov street,kazan,russian federation,laboratory of immunology and the development of allergens,kazan research institute of epidemiology and microbiology,67 big red street,kazan, Russian Federation, institute of fundamental medicine and biology,kazan federal university,18 kremlevskaya street,kazan, Russian Federation, i.m. sechenov first moscow state medical university,8-2 trubetskaya street,moscow, Russian Federation, laboratory of immunology and the development of allergens,kazan research institute of epidemiology and microbiology,67 big red street,kazan, Russian Federation, laboratory of immunology and the development of allergens,kazan research institute of epidemiology and microbiology,67 big red street,kazan, Russian Federation
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Authors
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