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Beneficial effects of prebiotic saccharomyces cerevisiae mannan on allergic asthma mouse models
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نویسنده
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lew d.b. ,michael c.f. ,overbeck t. ,robinson w.s. ,rohman e.l. ,lehman j.m. ,patel j.k. ,eiseman b. ,lemessurier k.s. ,samarasinghe a.e. ,gaber m.w.
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منبع
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journal of immunology research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (asm) remodeling effects. the mannose receptor (mr) family plays an important role in allergen uptake and processing of major allergens der p 1 and fel d 1. we have previously reported that asm cells express a mannose receptor (asm-mr) and that mannan derived from saccharomyces cerevisiae (sc-mn) inhibits mannosyl-rich lysosomal hydrolase-induced bovine asm cell proliferation. using a humanized transgenic mouse strain (huasm-mrc2) expressing the human mrc2 receptor in a sm tissue-specific manner,we have demonstrated that asm hyperplasia/hypertrophy can occur as early as 15 days after allergen challenge in this mouse model and this phenomenon is preventable with sc-mn treatment. this proof-of-concept study would facilitate future development of a potential asthma therapeutic agent with dual function of anti-inflammatory and anti-smooth muscle remodeling effects. © 2017 d. betty lew et al.
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آدرس
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department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics,children's foundation research institute,university of tennessee health science center (uthsc),le bonheur children's hospital,memphis,tn, United States, department of pediatrics and hematology-oncology,baylor college of medicine and texas children's cancer center,houston,tx, United States
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Authors
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