>
Fa   |   Ar   |   En
   Levels of Urinary Metabolites of Organophosphate Flame Retardants,TDCIPP,and TPHP,in Pregnant Women in Shanghai  
   
نویسنده feng l. ,ouyang f. ,liu l. ,wang x. ,wang x. ,li y.-j. ,murtha a. ,shen h. ,zhang j. ,zhang j.j.
منبع journal of environmental and public health - 2016 - دوره : 2016 - شماره : 0
چکیده    Flame retardants are widely used in consumer products to reduce their flammability. previously used flame retardants have been sequentially banned due to their environmental and human toxicity. currently,tris(1,3-dichloropropyl) phosphate (tdcipp) and triphenyl phosphate (tphp) are among the most commonly used flame retardants. tdcipp and tphp are reproductive toxins and have carcinogenic,neurotoxic,and endocrine-disrupting properties. although high levels of tdcipp and tphp have been found in drinking water,seawater,and office air in china,data regarding human exposure are lacking. in this study,we assessed the level of urinary tphp and tdcipp metabolites (dphp and bdcipp,resp.) in a cohort of pregnant women (n=23) from shanghai,china,using liquid chromatography-tandem mass spectrometry. dphp were detected in 100% urine samples,while only four urine samples had detectable level of bdcipp in this cohort (17% detected). geometric means of dphp and bdcipp concentrations were 1.1 ng/ml (interquartile range [iqr]: 0.6,1.5 ng/ml) and 1.2 ng/ml (iqr: 0.6,2.2 ng/ml),respectively. in this small cohort,urinary dphp and bdcipp levels were not significantly correlated with miscarriages,neonatal birthweight,gestational diabetes,or maternal age. these data suggest that exposure to tphp is widespread,and they demonstrate the feasibility of using urinary biomarkers to measure exposures to modern flame-retardant chemicals. � 2016 liping feng et al.
آدرس department of obstetrics and gynecology,duke global health institute,duke university,durham,nc, United States, moe-shanghai key laboratory of children's environmental health,xinhua hospital,shanghai jiao tong university,shanghai, China, key lab of urban environment and health,institute of urban environment,chinese academy of sciences,xiamen, China, moe-shanghai key laboratory of children's environmental health,xinhua hospital,shanghai jiao tong university,shanghai, China, moe-shanghai key laboratory of children's environmental health,xinhua hospital,shanghai jiao tong university,shanghai, China, department of biostatistics and bioinformatics,duke university,durham,nc, United States, department of obstetrics and gynecology,duke global health institute,duke university,durham,nc, United States, key lab of urban environment and health,institute of urban environment,chinese academy of sciences,xiamen, China, nicholas school of the environment,duke global health institute,duke university,durham,nc,united states,duke kunshan university,kunshan, China, moe-shanghai key laboratory of children's environmental health,xinhua hospital,shanghai jiao tong university,shanghai, China
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved