>
Fa   |   Ar   |   En
   Lipoprotein-associated phospholipase A2 mass level is increased in elderly subjects with type 2 diabetes mellitus  
   
نویسنده fortunato j. ,bláha v. ,bis j. ,št'ásek j. ,andrýs c. ,vojáček j. ,jurašková b. ,sobotka l. ,polanský p. ,brtko m.
منبع journal of diabetes research - 2014 - دوره : 2014 - شماره : 0
چکیده    Objective. lipoprotein-associated phospholipase a2 (lp-pla 2) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. we selected a group of elderly subjects that underwent transcatheter aortic valve implantation (tavi) or balloon angioplasty (ba) and separated them into two groups,diabetic and nondiabetic,to compare the level of lp-pla2 mass between them. methods. 44 patients aged 79.6 ± 5.6 years with symptomatic severe aortic valve stenosis underwent tavi (n = 35) or ba (n = 9). 21 subjects had confirmed type 2 diabetes mellitus. lp-pla2 mass was measured using an enzyme-linked immunosorbent assay kit (uscn life science,china) before and 3 days after the procedure. results. lp-pla2 mass was significantly elevated in this population (1296 ± 358 ng/ml before tavi; 1413 ± 268 ng/ml before ba) and further increased after tavi (1604 ± 437 ng/ml,p < 0. 01) or ba (1808 ± 303 ng/ml,p < 0. 01). lp-pla2 mass was significantly increased on the diabetic group before these interventions. conclusion. lp-pla2 may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. levels of lp-pla 2 in diabetic patients may accompany the higher amount of small dense ldl particles seen in these subjects. © 2014 j. fortunato et al.
آدرس 3rd department of internal medicine,metabolism and gerontology,university hospital hradec králové,medical faculty,charles university, Czech Republic, 3rd department of internal medicine,metabolism and gerontology,university hospital hradec králové,medical faculty,charles university, Czech Republic, 1st department of internal medicine,cardioangiology,university hospital hradec králové,medical faculty,charles universityc, Czech Republic, 1st department of internal medicine,cardioangiology,university hospital hradec králové,medical faculty,charles universityc, Czech Republic, department of immunology and alergology,university hospital hradec králové,medical faculty,charles university, Czech Republic, 1st department of internal medicine,cardioangiology,university hospital hradec králové,medical faculty,charles universityc, Czech Republic, 3rd department of internal medicine,metabolism and gerontology,university hospital hradec králové,medical faculty,charles university, Czech Republic, 3rd department of internal medicine,metabolism and gerontology,university hospital hradec králové,medical faculty,charles university, Czech Republic, department of cardiosurgery,university hospital hradec králové,medical faculty,charles university, Czech Republic, department of cardiosurgery,university hospital hradec králové,medical faculty,charles university, Czech Republic
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved