Effect of metformin intervention during pregnancy on the gestational diabetes mellitus in women with polycystic ovary syndrome: A systematic review and meta-analysis

Metformin is an effective insulin sensitizer treating type 2 diabetes mellitus. however,the functional consequences of metformin administration throughout pregnancy on gestational diabetes mellitus (gdm) with polycystic ovary syndrome (pcos) have not been assessed. we therefore performed a meta-analysis and system review to determine the effect of metformin on gdm in pcos. a meta-analysis was performed on the published studies before december,2013. meta-analysis examined whether metformin could reduce gdm occurrence in pcos with a fixed effect model. the odds ratio (or) with 95% confidence interval (95% ci) was calculated to estimate the strength of association. a total of 13 studies including 5 rcts and 8 non-rcts were enrolled. ultimately,effectiveness analysis demonstrated that,in total,there was no significant availability of metformin on gdm in pcos in contrast to placebo (or = 1.07,95% ci 0.60-1.92) in rcts and significant availability of metformin on gdm (or = 0.19,95% ci 0.13-0.27) was indicated in non-rcts. in summary,according to the results of our meta-analysis,strictly,metformin did not significantly effect on gdm with pcos,though more multicenters rcts still need to be investigated. © 2014 zhihong zhuo et al.