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Mediation role of C-reactive protein on the association between smoking quantity and type 2 diabetes in current Chinese smokers
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نویسنده
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feng d. ,liu t. ,wang h. ,karp e. ,ling w. ,chen w.-q.
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منبع
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journal of diabetes research - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Objective. previous studies have indicated that cigarette smokers are more likely to develop type 2 diabetes and that both smoking and type 2 diabetes are associated with c-reactive protein (crp). this study examined whether crp mediates the association between smoking quantity and type 2 diabetes. methods. nine hundred and eighty-four current chinese smokers were selected from a community-based chronic disease survey conducted in guangzhou and zhuhai. type 2 diabetes was defined according to the who 1999 criteria. crp was measured with flow cytometry. binary logistic regression was performed to assess the mediation. results. a positive association was observed between smoking quantity and type 2 diabetes (p<0.05). after controlling for potential confounders,daily cigarette consumption was significantly associated with higher crp levels. current smokers with type 2 diabetes had higher crp levels than smokers without type 2 diabetes. the association between the smoking quantity and type 2 diabetes was mediated by crp,which accounted for 50.77% of the association. conclusions. this study provides further evidence that smoking quantity is positively associated with type 2 diabetes and suggests that the association between smoking and type 2 diabetes might be mediated by crp. © 2014 dan feng,et al.
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آدرس
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department of preventive medicine,school of public health,sun yat-sen university,guangzhou 510080,china,guangdong provincial key laboratory of food,school of public health,sun yat-sen university, China, department of biostatistics and epidemiology,school of public health,sun yat-sen university,74 zhongshan road 2,guangzhou 510080,china,guangdong provincial institute of public health,guangdong provincial center for disease control and prevention, China, department of biostatistics and epidemiology,school of public health,sun yat-sen university,74 zhongshan road 2,guangzhou 510080,china,guangdong key laboratory of molecular epidemiology,school of public health,guangdong pharmaceutical university, China, guangdong provincial key laboratory of food,school of public health,sun yat-sen university,guangzhou 510080,china,department of biostatistics and epidemiology,school of public health,sun yat-sen university,74 zhongshan road 2, China, guangdong provincial key laboratory of food,school of public health,sun yat-sen university,guangzhou 510080,china,department of clinical nutrition,school of public health,sun yat-sen university, China, guangdong provincial key laboratory of food,school of public health,sun yat-sen university,guangzhou 510080,china,department of biostatistics and epidemiology,school of public health,sun yat-sen university,74 zhongshan road 2, China
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Authors
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