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Effects of unilateral nephrectomy on renal function in male spontaneously diabetic torii fatty rats: A novel obese type 2 diabetic model
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نویسنده
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katsuda y. ,kemmochi y. ,maki m. ,sano r. ,toriniwa y. ,ishii y. ,miyajima k. ,kakimoto k. ,ohta t.
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منبع
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journal of diabetes research - 2014 - دوره : 2014 - شماره : 0
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چکیده
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The spontaneously diabetic torii (sdt) fatty rat is a new model for obese type 2 diabetes. the aim of the present study was to investigate the effect of 1/2 nephrectomy (nx) on renal function and morphology and on blood pressure in sdt fatty rats. male sdt fatty rats underwent 1/2nx or a shamoperation (sham). subsequently,animals were studied with respect to renal function and histological alterations. induction of 1/2 nx in sdt fatty rats led to functional and morphological damage to the remnant kidney and to hypertension,which are considered main characteristics of chronic kidney disease,at a younger age compared with the sham group. in conclusion,the sdt fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery. copyright © 2014 yoshiaki katsuda et al.
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آدرس
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japan tobacco inc.,central pharmaceutical research institute,biological/pharmacological research laboratories,1-1 murasaki-cho,takatsuki, Japan, japan tobacco inc.,central pharmaceutical research institute,toxicology research laboratories,23 naganuki,hadano, Japan, japan tobacco inc.,central pharmaceutical research institute,biological/pharmacological research laboratories,1-1 murasaki-cho,takatsuki, Japan, japan tobacco inc.,central pharmaceutical research institute,biological/pharmacological research laboratories,1-1 murasaki-cho,takatsuki, Japan, japan tobacco inc.,central pharmaceutical research institute,biological/pharmacological research laboratories,1-1 murasaki-cho,takatsuki, Japan, japan tobacco inc.,central pharmaceutical research institute,biological/pharmacological research laboratories,1-1 murasaki-cho,takatsuki, Japan, japan tobacco inc.,central pharmaceutical research institute,toxicology research laboratories,23 naganuki,hadano, Japan, japan tobacco inc.,central pharmaceutical research institute,toxicology research laboratories,23 naganuki,hadano, Japan, japan tobacco inc.,central pharmaceutical research institute,biological/pharmacological research laboratories,1-1 murasaki-cho,takatsuki, Japan
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Authors
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