T-Cell cytokine gene polymorphisms and vitamin D pathway gene polymorphisms in end-stage renal disease due to type 2 diabetes mellitus nephropathy: Comparisons with health status and other main causes of end-stage renal disease

Background. t-cell cytokine gene polymorphisms and vitamin d pathway gene polymorphisms were evaluated as possibly associated with end-stage renal disease (esrd) resulting from type 2 diabetes mellitus (dm) nephropathy.methods. studies were conducted among hemodialysis (hd) patients with esrd due to type 2 dm nephropathy,chronic glomerulonephritis,chronic infective tubulointerstitial nephritis,and hypertensive nephropathy as well as in healthy subjects. a frequency distribution of t-cell-related interleukin (il) genes (il18 rs360719,il12a rs568408,il12b rs3212227,il4r rs1805015,il13 rs20541,il28b rs8099917,il28b,and rs12979860) and vitamin d pathway genes (gc genes: rs2298849,rs7041,and rs1155563; vdr genes: rs2228570,rs1544410; and rxra genes: rs10776909,rs10881578,and rs749759) was compared between groups.results. no significant differences in a frequency distribution of tested polymorphisms were shown between type 2 dm nephropathy patients and controls. a difference was found in il18 rs360719 polymorphic distribution between the former group and chronic infective tubulointerstitial nephritic patients (ptrend=0.033),which also differed in this polymorphism from controls (ptrend=0.005).conclusion. t-cell cytokine and vitamin d pathway gene polymorphisms are not associated with esrd due to type 2 dm nephropathy in polish hd patients. il18 rs360719 is probably associated with the pathogenesis of chronic infective tubulointerstitial nephritis. © 2014 alicja e. grzegorzewska et al.