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Brain aging and AD-like pathology in streptozotocin-induced diabetic rats
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نویسنده
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wang j.-q. ,yin j. ,song y.-f. ,zhang l. ,ren y.-x. ,wang d.-g. ,gao l.-p. ,jing y.-h.
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منبع
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journal of diabetes research - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Objective. numerous epidemiological studies have linked diabetes mellitus (dm) with an increased risk of developing alzheimer's disease (ad). however,whether or not diabetic encephalopathy shows ad-like pathology remains unclear. research design and methods. forebrain and hippocampal volumes were measured using stereology in serial coronal sections of the brain in streptozotocin- (stz-) induced rats. neurodegeneration in the frontal cortex,hypothalamus,and hippocampus was evaluated using fluoro-jade c (fjc). aβ aggregation in the frontal cortex and hippocampus was tested using immunohistochemistry and elisa. dendritic spine density in the frontal cortex and hippocampus was measured using golgi staining,and western blot was conducted to detect the levels of synaptophysin. cognitive ability was evaluated through the morris water maze and inhibitory avoidant box. results. rats are characterized by insulin deficiency accompanied with polydipsia,polyphagia,polyuria,and weight loss after stz injection. the number of fjc-positive cells significantly increased in discrete brain regions of the diabetic rats compared with the age-matched control rats. hippocampal atrophy,aβ aggregation,and synapse loss were observed in the diabetic rats compared with the control rats. the learning and memory of the diabetic rats decreased compared with those of the age-matched control rats. conclusions. our results suggested that aberrant metabolism induced brain aging as characterized by ad-like pathologies. copyright © 2014 jian-qin wang et al.
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آدرس
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nephrology department,blood dialysis center,second hospital of lanzhou university, China, institute of anatomy and embryology,school of basic medical sciences,lanzhou university, China, institute of anatomy and embryology,school of basic medical sciences,lanzhou university, China, institute of anatomy and embryology,school of basic medical sciences,lanzhou university, China, institute of anatomy and embryology,school of basic medical sciences,lanzhou university, China, institute of anatomy and embryology,school of basic medical sciences,lanzhou university, China, key laboratory of preclinical study for new drugs of gansu province,lanzhou university,lanzhou,china,institute of biochemistry and molecular biology,school of basic medical sciences,lanzhou university, China, institute of anatomy and embryology,school of basic medical sciences,lanzhou university,lanzhou,china,key laboratory of preclinical study for new drugs of gansu province,lanzhou university, China
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Authors
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