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Importance of maternal diabetes on the chronological deregulation of the intrauterine development: An experimental study in rat
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نویسنده
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salazar garcía m. ,reyes maldonado e. ,revilla monsalve m.c. ,villavicencio guzmán l. ,reyes lópez a. ,sánchez-gómez c.
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منبع
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journal of diabetes research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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We investigated whether maternal diabetes induced in rats using streptozotocin (stz) on day 5 of pregnancy affects the intrauterine developmental timeline. a total of 30 pregnant sprague-dawley diabetic rats (drs) and 20 control rats (crs) were used to obtain 21-day fetuses (f21) and newborn (nb) pups. gestational age,weight,and body size were recorded as were the maxillofacial morphometry and morphohistological characteristics of the limbs. in drs,pregnancy continued for ∼1.7 days,and delivery occurred 23 days postcoitus (dpc). in this group,the number of pups was lower,and 13% had maxillofacial defects. f21 in the dr group had lower weights and were smaller; moreover,the morphological characteristics of the maxillofacial structures,derived from the neural crest,were discordant with their chronological gestational age,resembling 18- to 19-day-old fetuses. these deficiencies were counterbalanced in nb pups. we conclude that hyperglycemia,which results from maternal diabetes and precedes embryo implantation,deregulates the intrauterine developmental timeline,restricts embryo-fetal growth,and primarily delays the remodeling and maturation of the structures derived from neural crest cells. © 2015 marcela salazar garcía et al.
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آدرس
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laboratorio de investigacion en biologia del desarrollo y teratogenesis experimental,hospital infantil de méxico federico gómez,dr. márquez 162,colonia doctores,df,mexico,escuela nacional de ciencias biológicas,instituto politécnico nacional,prolongación de carpio y plan de ayala,colonia santo tomas, Mexico, escuela nacional de ciencias biológicas,instituto politécnico nacional,prolongación de carpio y plan de ayala,colonia santo tomas, Mexico, unidad de investigación médica en enfermedades metabólicas,centro médico nacional siglo xxi,instituto mexicano del seguro social,avenida cuauhtémoc 330,colonia doctores, Mexico, laboratorio de investigacion en biologia del desarrollo y teratogenesis experimental,hospital infantil de méxico federico gómez,dr. márquez 162,colonia doctores, Mexico, dirección de investigación,hospital infantil de méxico federico gómez,dr. márquez 162,colonia doctores, Mexico, laboratorio de investigacion en biologia del desarrollo y teratogenesis experimental,hospital infantil de méxico federico gómez,dr. márquez 162,colonia doctores, Mexico
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Authors
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