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MicroRNA-223 expression is upregulated in insulin resistant human adipose tissue
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نویسنده
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chuang t.-y. ,wu h.-l. ,chen c.-c. ,gamboa g.m. ,layman l.c. ,diamond m.p. ,azziz r. ,chen y.-h.
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منبع
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journal of diabetes research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Micrornas (mirnas) are short noncoding rnas involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipid metabolism. we previously reported that adipose tissue (at) from women with polycystic ovary syndrome (pcos) or controls with insulin resistance (ir) revealed a differentially expressed microrna (mirna) profile,including upregulated mir-93 in pcos patients and in non-pcos women with ir. overexpressed mir-93 directly inhibited glucose transporter isoform 4 (glut4) expression,thereby influencing glucose metabolism. we have now studied the role of mir-223,which is also abnormally expressed in the at of ir subjects. our data indicates that mir-223 is significantly overexpressed in the at of ir women,regardless of whether they had pcos or not. mir-223 expression in at was positively correlated with homa-ir. unlike what is reported in cardiomyocytes,overexpression of mir-223 in human differentiated adipocytes was associated with a reduction in glut4 protein content and insulin-stimulated glucose uptake. in addition,our data suggests mir-223 regulates glut4 expression by direct binding to its 3′ untranslated region (3′utr). in conclusion,in at mir-223 is an ir-related mirna that may serve as a potential therapeutic target for the treatment of ir-related disorders. © 2015 tung-yueh chuang et al.
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آدرس
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department of obstetrics/gynecology,georgia regents university,1120 15th street,augusta, United States, department of obstetrics/gynecology,georgia regents university,1120 15th street,augusta, United States, department of biostatistics,georgia regents university,1120 15th street,augusta, United States, department of surgery,georgia regents university,1120 15th street,augusta, United States, department of obstetrics/gynecology,georgia regents university,1120 15th street,augusta,ga,united states,section of reproductive endocrinology,infertility and genetics,georgia regents university,1120 15th street,augusta,ga,united states,institute of molecular medicine and genetics,georgia regents university,1120 15th street,augusta,ga,united states,neuroscience program,georgia regents university,1120 15th street,augusta, United States, department of obstetrics/gynecology,georgia regents university,1120 15th street,augusta, United States, department of obstetrics/gynecology,georgia regents university,1120 15th street,augusta,ga,united states,department of medicine,georgia regents university,1120 15th street,augusta, United States, department of obstetrics/gynecology,georgia regents university,1120 15th street,augusta, United States
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Authors
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