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Circulating malondialdehyde-modified LDL-related variables and coronary artery stenosis in asymptomatic patients with type 2 diabetes
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نویسنده
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fujihara k. ,suzuki h. ,sato a. ,kodama s. ,heianza y. ,saito k. ,iwasaki h. ,kobayashi k. ,yatoh s. ,takahashi a. ,yahagi n. ,yagyu h. ,sone h. ,shimano h.
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منبع
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journal of diabetes research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Aims. to elucidate the levels of malondialdehyde-modified ldl (mda-ldl)-related variables for predicting coronary artery stenosis (cas) by coronary ct angiography (ccta) in asymptomatic patients with type 2 diabetes (t2dm). methods. enrolled were 36 japanese patients with t2dm who underwent ccta and in whom mda-ldl levels were measured. definition of cas was luminal narrowing of ≥50%. trends through tertiles of each mda-ldl-related variable were analyzed with a general linear model. the ability of each mda-ldl-related variable to predict cas was compared to areas under the curve (aucs) in receiver operating characteristic curve (roc) analysis. results. seventeen patients had cas. each mda-ldl-related variable was an independent predictor of cas (p = 0.039 for mdaldl,p = 0.013 for mda-ldl/ldl-c,p = 0.047 for mda-ldl/hdl-c,and p = 0.013 for (mda-ldl/ldl-c)/hdl-c). aucs of mda-ldl,mda-ldl/ldl-c,mda-ldl/hdl-c,and (mda-ldl/ldl-c)/hdl-c were 0.675 (95% ci 0.496-0.854),0.765 (0.602-0.927),0.752 (0.592-0.913),and 0.799 (0.643-0.955),respectively,for predicting cas. trends throughout the tertiles showed significant associations between mda-ldl/ldl-c,mda-ldl/hdl-c,or (mdaldl/ldl-c)/hdl-c and cas (p = 0.003 for mda-ldl/ldl-c,p = 0.042 for mda-ldl/hdl-c,and p = 0.001 for (mda-ldl/ldl-c)/hdl-c). conclusions. data suggest that measurements of mda-ldl/ldl-c,mda-ldl/hdlc,and (mda-ldl/ldl-c)/hdl-c are useful for predicting cas. © 2015 kazuya fujihara et al.
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آدرس
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department of internal medicine,faculty of medicine,university of tsukuba,tsukuba, Japan, department of internal medicine,faculty of medicine,university of tsukuba,tsukuba, Japan, department of internal medicine,faculty of medicine,university of tsukuba,tsukuba, Japan, department of hematology,endocrinology and metabolism,school of medicine,niigata university,niigata, Japan, department of hematology,endocrinology and metabolism,school of medicine,niigata university,niigata, Japan, division of endocrinology and metabolism,center for medical sciences,ibaraki prefectural university of health sciences,ami, Japan, department of internal medicine,faculty of medicine,university of tsukuba,tsukuba, Japan, department of internal medicine,faculty of medicine,university of tsukuba,tsukuba, Japan, department of internal medicine,faculty of medicine,university of tsukuba,tsukuba, Japan, department of internal medicine,faculty of medicine,university of tsukuba,tsukuba, Japan, department of internal medicine,faculty of medicine,university of tsukuba,tsukuba, Japan, department of internal medicine,faculty of medicine,university of tsukuba,tsukuba, Japan, department of hematology,endocrinology and metabolism,school of medicine,niigata university,niigata, Japan, department of internal medicine,faculty of medicine,university of tsukuba,tsukuba,ibaraki,japan,international institute for integrative sleep medicine (wpi-iiis),university of tsukuba,tsukuba, Japan
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Authors
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