The effects of probiotic soymilk fortified with omega-3 on blood glucose,lipid profile,haematological and oxidative stress,and inflammatory parameters in streptozotocin nicotinamide-induced diabetic rats

Objective. the aim of the present study was to evaluate the effects of probiotic soymilk fortified with omega-3 in diabetic rats. methods. soymilk (sm),fermented soymilk (fsm),and fermented soymilk fortified with omega-3 (fsm + omega-3) were prepared. rats were randomly assigned to five groups of 13 animals per group. diabetes was induced by a single injection of streptozotocin (stz) 15 min after the intraperitoneal administration of nicotinamide (na). normal control (nc) and diabetic control (dc) rats received 1 ml/day of distilled water and three groups of diabetic rats were given 1 ml/day of sm,fsm,and fsm + omega-3 products by oral gavage for 28 days. results. three products significantly (p < 0.05) reduced blood glucose,total cholesterol (tc),triglyceride (tg),and malondialdehyde (mda) concentrations compared to the dc group,with the maximum reduction seen in the fsm + omega-3 group. body weight,red blood cells (rbc),haemoglobin (hb),haematocrit,and superoxide dismutase (sod) also significantly increased in the fsm + omega-3 group. in the fsm + omega-3 group,mda level compared with the sm and fsm groups and high sensitivity c-reactive protein (hs-crp) concentrations compared with the dc and fsm groups were significantly lower (p < 0.05). conclusion. fermented soymilk fortified with omega-3 may be beneficial in diabetes. © 2015 mohsen mohammadi sartang et al.