Healthy chilean adolescents with HOMA-IR ≥ 2.6 have increased cardiometabolic risk: Association with genetic,biological,and environmental factors

Objective. to determine the optimal cutoff of the homeostasis model assessment-insulin resistance (homa-ir) for diagnosis of the metabolic syndrome (mets) in adolescents and examine whether insulin resistance (ir),determined by this method,was related to genetic,biological,and environmental factors. methods. in 667 adolescents (16.8 ± 0.3 y),bmi,waist circumference,glucose,insulin,adiponectin,diet,and physical activity were measured. fat and fat-free mass were assessed by dual-energy x-ray absorptiometry. family history of type 2 diabetes (fhdm) was reported. we determined the optimal cutoff of homa-ir to diagnose mets (idf criteria) using roc analysis. ir was defined as homa-ir values above the cutoff. we tested the influence of genetic,biological,and environmental factors on ir using logistic regression analyses. results. of the participants,16% were obese and 9.4 % met criteria for mets. the optimal cutoff for mets diagnosis was a homa-ir value of 2.6. based on this value,16.3% of participants had ir. adolescents with ir had a significantly higher prevalence of obesity,abdominal obesity,fasting hyperglycemia,and mets compared to those who were not ir. fhdm,sarcopenia,obesity,and low adiponectin significantly increased the risk of ir. conclusions. in adolescents,homa-ir ≥ 2.6 was associated with greater cardiometabolic risk. © 2015 r. burrows et al.