Current Smoking Dose-Dependently Associated with Decreased β -Cell Function in Chinese Men without Diabetes

The aim of this study was to evaluate the associations between chronic smoking and insulin resistance and β-cell function in chinese men without diabetes. a total of 1,568 participants were recruited by multistage sampling. using homeostatic model assessment (homa),geometric means of insulin resistance (homa-ir) and β-cell function (homa-β) with 95% confidence interval (ci) were calculated by general linear model. odds ratios (ors) with 95% ci were estimated to evaluate the associations between smoking status and insulin resistance and β-cell deficiency under a logistic regression model. current smokers had higher levels of 2 h glucose (6.66 versus 6.48 mmol/l) for oral glucose tolerance test and lower levels of fasting insulin (5.68 versus 6.03 mu/l) than never smokers. the adjusted means for homa-β (%) were 54.86 in current smokers and 58.81 in never smokers (p=0.0257). current smoking was associated with β-cell deficiency (or 1.29,95% ci 1.01-1.64) compared to never smoking. the β-cell function gradually decreased with increasing smoking intensity (ptrend=0.0026),and the differences were statistically significant when the pack-year of smoking was 20 or above. no association was observed between smoking status and homa-ir. our study suggested that chronic smoking may dose-dependently suppress insulin secretion in chinese men. copyright © 2015 chun wang et al.