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A new approach to define and diagnose cardiometabolic disorder in children
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نویسنده
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andersen l.b. ,lauersen j.b. ,brønd j.c. ,anderssen s.a. ,sardinha l.b. ,steene-johannessen j. ,mcmurray r.g. ,barros m.v.g. ,kriemler s. ,møller n.c. ,bugge a. ,kristensen p.l. ,ried-larsen m. ,grøntved a. ,ekelund u.
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منبع
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journal of diabetes research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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The aim of the study was to test the performance of a new definition of metabolic syndrome (mets),which better describes metabolic dysfunction in children. methods. 15,794 youths aged 6-18 years participated. mean z-score for cvd risk factors was calculated. sensitivity analyses were performed to evaluate which parameters best described the metabolic dysfunction by analysing the score against independent variables not included in the score. results. more youth had clustering of cvd risk factors (>6.2%) compared to the number selected by existing mets definitions (international diabetes federation (idf) < 1%). waist circumference and bmi were interchangeable,but using insulin resistance homeostasis model assessment (homa) instead of fasting glucose increased the score. the continuous mets score was increased when cardiorespiratory fitness (crf) and leptin were included. a mean z-score of 0.40-0.85 indicated borderline and above 0.85 indicated clustering of risk factors. a noninvasive risk score based on adiposity and crf showed sensitivity and specificity of 0.85 and an area under the curve of 0.92 against idf definition of mets. conclusions. diagnosis for mets in youth can be improved by using continuous variables for risk factors and by including crf and leptin. © 2015 lars bo andersen et al.
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آدرس
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center of research in childhood health,department of sport sciences and clinical biomechanics,university of southern denmark,campusvej 55,odense,denmark,department of sports medicine,norwegian school of sport sciences,sognsveien 220, Norway, department of sports medicine,norwegian school of sport sciences,sognsveien 220, Norway, center of research in childhood health,department of sport sciences and clinical biomechanics,university of southern denmark,campusvej 55, Denmark, department of sports medicine,norwegian school of sport sciences,sognsveien 220, Norway, exercise and health laboratory,ciper,universidade de lisboa, Portugal, department of sports medicine,norwegian school of sport sciences,sognsveien 220, Norway, department of exercise and sport science,university of north carolina,025 fetzer gym,chapel hill, United States, school of physical education,university of pernambuco,campus universitario huoc-esef,arnobio marques 310, Brazil, biostatistics and prevention institute,university of zurich,hirschengraben 84, Switzerland, center of research in childhood health,department of sport sciences and clinical biomechanics,university of southern denmark,campusvej 55, Denmark, center of research in childhood health,department of sport sciences and clinical biomechanics,university of southern denmark,campusvej 55, Denmark, center of research in childhood health,department of sport sciences and clinical biomechanics,university of southern denmark,campusvej 55, Denmark, center of research in childhood health,department of sport sciences and clinical biomechanics,university of southern denmark,campusvej 55,odense,denmark,centre of inflammation and metabolism and trygfondens,university of copenhagen,department of infectious diseases and cmrc,tagensvej 20, Denmark, center of research in childhood health,department of sport sciences and clinical biomechanics,university of southern denmark,campusvej 55, Denmark, department of sports medicine,norwegian school of sport sciences,sognsveien 220,oslo,norway,mrc epidemiology unit,institute of metabolic science,university of cambridge,hills road, United Kingdom
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Authors
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