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Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy
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نویسنده
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wang s. ,li b. ,li c. ,cui w. ,miao l.
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منبع
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journal of diabetes research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Diabetic nephropathy (dn) is the leading cause of end-stage renal disease (esrd). the development and progression of dn might involve multiple factors. connective tissue growth factor (ccn2,originally known as ctgf) is the one which plays a pivotal role. therefore,increasing attention is being paid to ccn2 as a potential therapeutic target for dn. up to date,there are also many drugs or agents which have been shown for their protective effects against dn via different mechanisms. in this review,we only focus on the potential renoprotective therapeutic agents which can specifically abolish ccn2 expression or nonspecifically inhibit ccn2 expression for retarding the development and progression of dn. © 2015 songyan wang et al.
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آدرس
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department of nephrology,second hospital of jilin university,changchun,china,department of nephrology,jilin province people's hospital, China, department of nephrology,jilin province people's hospital, China, department of urology,2nd hospital of changchun, China, department of nephrology,second hospital of jilin university, China, department of nephrology,second hospital of jilin university, China
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Authors
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