The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Background. the results from published studies regarding association of transcription factor 7-like 2 (tcf7l2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive. methods. we carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. data was extracted by a standard algorithm. dominant,recessive,homozygote,and heterozygote comparison models were utilized. results. 24 studies incorporating 52,785 subjects were included in this meta-analysis. overall,the minor allele (t) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: smd = -0.04,95% ci (-0.08,0.00),p = 0.048,p heterogeneity = 0.47; recessive model: smd = -0.10,95% ci (-0.18,-0.02),p = 0.01,p heterogeneity = 0.56). no association was found between minor (t) allele and plasma tc,ldl-c,or hdl-c levels in subjects with type 2 diabetes or metabolic syndrome (mets) and no association was found between minor (t) allele and plasma tg levels in nondiabetic subjects. conclusions. our meta-analysis indicated the association between tcf7l2 rs7903146 polymorphism and low plasma triglyceride (tg) level in subjects with type 2 diabetes. no association was found between rs7903146 variant and plasma lipids in nondiabetic subjects. © 2015 shuxia wang et al.