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Renal kallikrein activation and renoprotection after dual blockade of renin-angiotensin system in diet-induced diabetic nephropathy
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نویسنده
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zou x. ,zhang x.-x. ,liu x.-y. ,li r. ,wang m. ,wu w.-j. ,sui y. ,zhao h.-l.
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منبع
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journal of diabetes research - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Purpose. the objective of this study is to investigate the effect of dual blockage of renin-angiotensin system (ras) on renal kallikrein expression and inflammatory response in diabetic nephropathy (dn). methods. rats were randomly divided into 5 groups with 10 rats in each group: normal control; dn model induced by high fat and high sucrose diets; and dn treated with either benazepril 10 mg/kg/d,irbesartan 30 mg/kg/d,or both. after 8-week treatment,we examined changes in the kidney histopathology,function and immunohistochemical stain of kallikrein,macrophage marker cd68,and profibrotic markers transforming growth factor- (tgf-) β and α -smooth muscle action (sma). results. dn rats showed enlarged kidneys with glomerulosclerosis,interstitial chronic inflammation and fibrosis,and proteinuria. all the pathological damage and functional impairments were improved after the ras blockades (all p < 0.05). compared with monotherapy,combined treatment further alleviated the kidney impairments in parallel to increased tubular immunoreactivity for kallikrein and decreased immunopositive cells for cd68,tgf- β,and α -sma. conclusion. the renoprotective effects of the dual ras blockade in diabetic nephropathy may be attributed to improved tubular kallikrein expression and interstitial inflammatory response. copyright © 2015 xia zou et al.
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آدرس
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guilan university of medical sciences, China, guilan university of medical sciences, China, guilan university of medical sciences, China, center for diabetic systems medicine,guangxi key laboratory of excellence,guilin medical university,guilin,china,department of biology,molecular endocrinology and toxicology laboratory,hong kong baptist university, Hong Kong, guilan university of medical sciences, China, guilan university of medical sciences, China, department of endocrinology,guangdong hospital of traditional chinese medicine, China, guilan university of medical sciences, China
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Authors
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