Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults

We aimed to clarify how the trajectories of 1-hour postload plasma glucose (pg) and 2-hour pg were different in the development of type 2 diabetes. using data of repeated health checkups in japanese workers from april 2006 to march 2016,longitudinal changes of fasting,1-hour,and 2-hour pg on the oral glucose tolerance test were analyzed with a linear mixed effects model. of the 1464 nondiabetic subjects at baseline,112 subjects progressed to type 2 diabetes during the observation period (progressors). in progressors,1-hour pg and 2-hour pg showed gradual increases with slopes of 1.33 ± 0.2 and 0.58 ± 0.2 mg/dl/year,respectively,followed by a steep increase by which they attained diabetes. until immediately before the diabetes transition,age- and sex-adjusted mean level of 2-hour pg was 149 ± 2.7 mg/dl,34 ± 2.7 (30%) higher compared to nonprogressors,while that of 1-hour pg was 206 ± 4.1 mg/dl,60 ± 4.3 mg/dl (41%) higher compared to nonprogressors. in conclusion,diabetes transition was preceded by a mild elevation of 2-hour pg for several years or more. the elevation in 1-hour pg was larger than that of 2-hour pg until immediately before the transition to diabetes. © 2017 rie oka et al.