Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis

The role of nesfatin-1 in glucose homeostasis has been investigated previously. however,although numerous studies have examined the relationships between circulating nesfatin-1 levels and type 2 diabetes,the conclusions are contradictory. we aimed to probe the relationship between circulating nesfatin-1 levels and type 2 diabetes by meta-analysis. seven studies including 328 type 2 diabetes patients and 294 control subjects were included. although there was no obvious difference in circulating nesfatin-1 levels between patients with type 2 diabetes and the control group (md = -0.04; 95% ci = -0.32 to -0.23),subgroup analysis showed higher nesfatin-1 levels in newly diagnosed type 2 diabetes patients (md = 0.59; 95% ci = 0.45 to 0.74) and significantly lower nesfatin-1 levels in type 2 diabetes patients receiving antidiabetic treatment (md = -0.26; 95% ci = -0.33 to -0.20). in conclusion,the analysis supports a relationship between circulating nesfatin-1 levels and type 2 diabetes,where newly diagnosed type 2 diabetes was associated with an elevated nesfatin-1 level,and type 2 diabetes patients receiving antidiabetic treatment showed lower circulating nesfatin-1 levels. © 2017 ting zhai et al.