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   Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice  
   
نویسنده pahwa r. ,balderas m. ,jialal i. ,chen x. ,luna r.a. ,devaraj s.
منبع journal of diabetes research - 2017 - دوره : 2017 - شماره : 0
چکیده    Aims. diabetes is a proinflammatory state,evidenced by increased pattern recognition receptors and the inflammasome (nod-like receptor family pyrin domain (nlrp)) complex. recent reports have elucidated the role of the gut microbiome in diabetes,but there is limited data on the gut microbiome in nlrp-ko mice and its effect on diabetes-induced inflammation. methods. gut microbiome composition and biomarkers of inflammation (il-18,serum amyloid a) were assessed in streptozotocin- (stz-) induced diabetic mice on a nlrp3-knockout (ko) background versus wild-type diabetic mice. results. saa and il-18 levels were significantly elevated in diabetic mice (stz) compared to control (wt) mice,and there was a significant attenuation of inflammation in diabetic nlrp3-ko mice (nlrp3-ko stz) compared to control mice (p<0.005). principal coordinate analysis clearly separated controls,stz,and nlrp3-ko stz mice. among the different phyla,there was a significant increase in the firmicutes: bacteroidetes ratio in the diabetic group compared to controls. when compared to the wt stz group,the nlrp3-ko stz group showed a significant decrease in the firmicutes: bacteroidetes ratio. together,these findings indicate that interaction of the intestinal microbes with the innate immune system is a crucial factor that could modify diabetes and complications. © 2017 roma pahwa et al.
آدرس veterans affairs medical center,mather,ca,united states,college of medicine,california northstate university,elk grove,ca, United States, texas children's microbiome center,texas children's hospital,houston,tx,united states,department of pathology and immunology,baylor college of medicine,houston,tx, United States, veterans affairs medical center,mather,ca,united states,college of medicine,california northstate university,elk grove,ca, United States, texas children's microbiome center,texas children's hospital,houston,tx,united states,department of pathology and immunology,baylor college of medicine,houston,tx, United States, texas children's microbiome center,texas children's hospital,houston,tx,united states,department of pathology and immunology,baylor college of medicine,houston,tx, United States, texas children's microbiome center,texas children's hospital,houston,tx,united states,department of pathology and immunology,baylor college of medicine,houston,tx, United States
 
     
   
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