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Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes
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نویسنده
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ramírez-morros a. ,granado-casas m. ,alcubierre n. ,martinez-alonso m. ,real j. ,castelblanco e. ,esquerda a. ,cao g. ,rubinat e. ,hernández m. ,alonso n. ,fernández e. ,mauricio d.
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منبع
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journal of diabetes research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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Aims. to assess whether circulating 25-hydroxyvitamin d3 (25ohd) and mineral metabolism-related factors (serum phosphate,calcium,and parathormone) are associated with subclinical carotid atherosclerosis (sca),defined as the presence of carotid atherosclerotic plaques (main study outcome),in patients with type 2 diabetes mellitus (t2dm) without kidney disease or previous cardiovascular disease. methods. we undertook a post hoc analysis of a cross-sectional study in adults with t2dm in whom we evaluated sca. a total of 303 subjects with t2dm were included. clinical variables and carotid ultrasound imaging were obtained. results. we found no association of 25ohd with the presence of sca. however,calcium phosphate (cap; mg2/dl2) product was positively associated with the presence of carotid plaques (oradj = 1.078; 95% ci: 1.017-1.142). an inverse association was observed between higher levels of 25ohd (≥30 ng/ml versus <20 ng/ml concentrations) and common carotid intima-media thickness (cimt; mm) (βadj ± se = -0.055 ± 0.024). we conclude that the cap product is independently associated with the presence of established subclinical carotid atherosclerosis in patients with t2dm. © 2017 anna ramírez-morros et al.
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آدرس
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health sciences research institute germans trias i pujol,camí de les escoles s/n,badalona,spain,department of endocrinology and nutrition,health sciences research institute,university hospital germans trias i pujol,carretera canyet s/n,badalona, Spain, health sciences research institute germans trias i pujol,camí de les escoles s/n,badalona,spain,department of endocrinology and nutrition,health sciences research institute,university hospital germans trias i pujol,carretera canyet s/n,badalona,spain,biomedical research institute of lleida,university of lleida,rovira roure 80,lleida, Spain, biomedical research institute of lleida,university of lleida,rovira roure 80,lleida, Spain, biostatistics and epidemiology unit,biomedical research institute of lleida,university of lleida,rovira roure 80,lleida, Spain, ciber of diabetes and assoc. metabolic diseases (ciberdem),instituto de salud carlos iii,madrid,spain,epidemiology and public health,universitat internacional de catalunya,sant cugat,spain,unitat de suport a la recerca barcelona,institut universitari d'investigacio en atencio primaria jordi gol (idiap jordi gol),barcelona, Spain, health sciences research institute germans trias i pujol,camí de les escoles s/n,badalona,spain,department of endocrinology and nutrition,health sciences research institute,university hospital germans trias i pujol,carretera canyet s/n,badalona,spain,ciber of diabetes and assoc. metabolic diseases (ciberdem),instituto de salud carlos iii,madrid, Spain, department of laboratory medicine,university hospital arnau de vilanova,rovira roure 80,lleida, Spain, department of laboratory medicine,university hospital arnau de vilanova,rovira roure 80,lleida, Spain, biomedical research institute of lleida,university of lleida,rovira roure 80,lleida,spain,ciber of diabetes and assoc. metabolic diseases (ciberdem),instituto de salud carlos iii,madrid, Spain, department of endocrinology and nutrition,university hospital arnau de vilanova,rovira roure 80,lleida, Spain, department of endocrinology and nutrition,health sciences research institute,university hospital germans trias i pujol,carretera canyet s/n,badalona,spain,ciber of diabetes and assoc. metabolic diseases (ciberdem),instituto de salud carlos iii,madrid, Spain, biomedical research institute of lleida,university of lleida,rovira roure 80,lleida,spain,unitat de deteccio i tractament de malalties aterotrombotiques,university hospital arnau de vilanova,lleida,spain,department of nephrology,university hospital arnau de vilanova,lleida, Spain, department of endocrinology and nutrition,health sciences research institute,university hospital germans trias i pujol,carretera canyet s/n,badalona,spain,ciber of diabetes and assoc. metabolic diseases (ciberdem),instituto de salud carlos iii,madrid,spain,unitat de suport a la recerca barcelona,institut universitari d'investigacio en atencio primaria jordi gol (idiap jordi gol),barcelona, Spain
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Authors
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