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Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives
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نویسنده
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femminella g.d. ,bencivenga l. ,petraglia l. ,visaggi l. ,gioia l. ,grieco f.v. ,de lucia c. ,komici k. ,corbi g. ,edison p. ,rengo g. ,ferrara n.
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منبع
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journal of diabetes research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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Diabetes mellitus (dm) and alzheimer's disease (ad) are two highly prevalent conditions in the elderly population and major public health burden. in the past decades,a pathophysiological link between dm and ad has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however,other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. both preclinical and clinical studies have evaluated the possible neuroprotective mechanisms of different classes of antidiabetic medications in ad,with some promising results. here,we review the evidence on the mechanisms of action of antidiabetic drugs and their potential use in ad. © 2017 grazia daniela femminella et al.
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آدرس
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neurology imaging unit,imperial college london,london, United Kingdom, division of geriatrics,department of translational medical sciences,federico ii university of naples,naples, Italy, division of geriatrics,department of translational medical sciences,federico ii university of naples,naples, Italy, division of geriatrics,department of translational medical sciences,federico ii university of naples,naples, Italy, division of geriatrics,department of translational medical sciences,federico ii university of naples,naples, Italy, division of geriatrics,department of translational medical sciences,federico ii university of naples,naples, Italy, division of geriatrics,department of translational medical sciences,federico ii university of naples,naples,italy,center for translational medicine,department of pharmacology,lewis katz school of medicine,temple university,philadelphia,pa, United States, division of geriatrics,department of translational medical sciences,federico ii university of naples,naples, Italy, department of medicine and health sciences,university of molise,campobasso, Italy, neurology imaging unit,imperial college london,london, United Kingdom, division of geriatrics,department of translational medical sciences,federico ii university of naples,naples,italy,istituti clinici scientifici maugeri spa società benefit,telese terme institute (bn), Italy, division of geriatrics,department of translational medical sciences,federico ii university of naples,naples, Italy
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Authors
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