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   Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy  
   
نویسنده dai h. ,liu q. ,liu b.
منبع journal of diabetes research - 2017 - دوره : 2017 - شماره : 0
چکیده    Diabetic nephropathy (dn) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases. increased amounts of urinary protein in dn may be associated with functional and morphological alterations of podocyte,mainly including podocyte hypertrophy,epithelial-mesenchymal transdifferentiation (emt),podocyte detachment,and podocyte apoptosis. accumulating studies have revealed that disruption in multiple renal signaling pathways had been critical in the progression of these pathological damages,such as adenosine monophosphate-activated kinase signaling pathways (ampk),wnt/β-catenin signaling pathways,endoplasmic reticulum stress-related signaling pathways,mammalian target of rapamycin (mtor)/autophagy pathway,and rho gtpases. in this review,we highlight new molecular insights underlying podocyte injury in the progression of dn,which offer new therapeutic targets to develop important renoprotective treatments for dn over the next decade. © 2017 haoran dai et al.
آدرس department of nephrology,shunyi branch,beijing hospital of traditional chinese medicine,station east 5,shunyi district,beijing, China, department of nephrology,shunyi branch,beijing hospital of traditional chinese medicine,station east 5,shunyi district,beijing,china,beijing hospital of traditional chinese medicine affiliated to capital medical university,23 meishuguanhou street,dongcheng district,beijing, China, department of nephrology,shunyi branch,beijing hospital of traditional chinese medicine,station east 5,shunyi district,beijing,china,beijing hospital of traditional chinese medicine affiliated to capital medical university,23 meishuguanhou street,dongcheng district,beijing, China
 
     
   
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