Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China

Background. recent studies indicated that the serine threonine kinase 11 (stk11),which is a key regulator of the amp-activated protein kinase (ampk),plays a crucial role in cardiovascular system. this study aimed to investigate whether genetic variations in the stk11 gene affect the risk of coronary artery disease (cad) in chinese type 2 diabetics. methods. 5 haplotype-tagging single nucleotide polymorphisms (snps) were selected,and 288 cad-positive cases and 159 cad-negative controls with type 2 diabetes were genotyped by polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) assay. results. the carriers of minor allele a at rs12977689 had a higher risk of cad compared to the homozygotes of cc (or = 1.572,95% ci = 1.039-2.376,p=0.035),and the difference was still significant after adjustment for the other known cad risk factors (or′ = 1.184,95% ci′ = 1.036-1.353,p′=0.013). conclusion. genetic variability at stk11 locus is associated with cad risk in type 2 diabetes in the chinese population. © 2017 xiaowei ma et al.